Dipeptide metabolite, glutamyl-glutamate mediates microbe-host interaction to boost spermatogenesis.

ABSTRACT: The decrease in sperm count and infertility is a global issue that remains unresolved. By screening environmental bacterial isolates, we have found that a novel lactic acid bacterium, Lactiplantibacillus plantarum SNI3, increased testis size, testosterone levels, sperm count, sexual activity and fertility in mice that have consumed the bacteria for four weeks. The abundance of L. plantarum in the colon microbiome was positively associated with sperm count. Fecal microbiota transplantation (FMT) from L. plantarum SNI3-dosed mice improved testicular functions in microbiome-attenuated recipient animals. To identify mediators that confer pro-reproductive effects on the host, untargeted in situ mass spectrometry metabolomics was performed on testis samples of L. plantarum SNI3-treated and contr

SUBMITTER: Juhasz B 

PROVIDER: S-EPMC11413372 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature