Correlation of HbA1c levels with CT-based body composition biomarkers in diabetes mellitus and metabolic syndrome.

ABSTRACT: Diabetes mellitus and metabolic syndrome are closely linked with visceral body composition, but clinical assessment is limited to external measurements and laboratory values including hemoglobin A1c (HbA1c). Modern deep learning and AI algorithms allow automated extraction of biomarkers for organ size, density, and body composition from routine computed tomography (CT) exams. Comparing visceral CT biomarkers across groups with differing glycemic control revealed significant, progressive CT biomarker changes with increasing HbA1c. For example, in the unenhanced female cohort, mean changes between normal and poorly-controlled diabetes showed: 53% increase in visceral adipose tissue area, 22% increase in kidney volume, 24% increase in liver volume, 6% decrease in liver density (hepatic steato

SUBMITTER: Warner JD 

PROVIDER: S-EPMC11413398 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature