Validation of regression-based change formulae for mild cognitive impairment and Alzheimer's disease.

ABSTRACT:

Introduction

Identification of cognitive decline is critical in older adults at risk for dementia. In a 2020 study reported in Archives of Clinical Neuropsychology, Kiselica and colleagues developed standardized regression-based (SRB) change formulae for the Uniform Data Set 3.0 Neuropsychological Battery in cognitively unimpaired older adults. However, validation of their applicability in impaired individuals is needed.

Methods

Using longitudinal data on 5974 participants (cognitively unimpaired, mild cognitive impairment, dementia) from the National Alzheimer's Coordinating Center, SRB change scores were calculated for each individual and compared across groups.

Results

Across 6 to 24 months, minimal cognitive change was observed in cognitively unimpaired par

SUBMITTER: Duff K 

PROVIDER: S-EPMC11413409 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature