SMARCA5-mediated chromatin remodeling is required for germinal center formation.

ABSTRACT: The establishment of long-lasting immunity against pathogens is facilitated by the germinal center (GC) reaction, during which B cells increase their antibody affinity and differentiate into antibody-secreting cells (ASC) and memory cells. These events involve modifications in chromatin packaging that orchestrate the profound restructuring of gene expression networks that determine cell fate. While several chromatin remodelers were implicated in lymphocyte functions, less is known about SMARCA5. Here, using ribosomal pull-down for analyzing translated genes in GC B cells, coupled with functional experiments in mice, we identified SMARCA5 as a key chromatin remodeler in B cells. While the naive B cell compartment remained unaffected following conditional depletion of Smarca5, effective prol

SUBMITTER: Stoler-Barak L 

PROVIDER: S-EPMC11413417 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature