Impact of on-trial IGRT quality assurance in an international adaptive radiotherapy trial for participants with bladder cancer.

ABSTRACT:

Background and purpose

Radiotherapy trial quality assurance (RT QA) is crucial for ensuring the safe and reliable delivery of radiotherapy trials, and minimizing inter-institutional variations. While previous studies focused on outlining and planning quality assurance (QA), this work explores the process of Image-Guided Radiotherapy (IGRT), and adaptive radiotherapy. This study presents findings from during-accrual QA in the RAIDER trial, evaluating concordance between online and offline plan selections for bladder cancer participants undergoing adaptive radiotherapy. RAIDER had two seamless stages; stage 1 assessed adherence to dose constraints of dose escalated radiotherapy (DART) and stage 2 assessed safety. The RT QA programme was updated from stage 1 to stage 2.

Materials a

SUBMITTER: Webster A 

PROVIDER: S-EPMC11413485 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature