Projected health and economic effects of a pan-tuberculosis treatment regimen: a modelling study.

ABSTRACT:

Background

A pan-tuberculosis regimen that could be initiated without knowledge of drug susceptibility has been proposed as an objective of tuberculosis regimen development. We modelled the health and economic benefits of such a regimen and analysed which of its features contribute most to impact and savings.

Methods

We constructed a mathematical model of tuberculosis treatment parameterised with data from the published literature specific to three countries with a high tuberculosis burden (India, the Philippines, and South Africa). Our model simulated cohorts of newly diagnosed tuberculosis patients, including drug susceptibility testing if performed, regimen assignment, discontinuation, adherence, costs, and resulting outcomes of durable cure (microbiological cure without

SUBMITTER: Ryckman TS 

PROVIDER: S-EPMC11413512 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature