New synthetic chitosan Schiff bases bearing pyranoquinolinone or benzonaphthyridine and their silver nanoparticles derivatives with potential activity as antioxidant and molecular docking study for EGFR inhibitors.

ABSTRACT: In this study, two new carboxaldehydes 3, and 4 were synthesized by Vilsmeier-Haack formylation of 6-butyl-benzo[h][1,6]naphthyridine-2,5-dione 2 and 6-butyl-pyrano[3,2-c]quinolinone 1, respectively. Structures of newly synthesized compounds were achieved by IR, ¹H NMR, ¹³C NMR, mass techniques, and elemental analyses. The two synthesized carboxaldehydes 3 and 4 were used as precursors for the synthesis of two new chitosan-based Schiff bases, CS₁ and CS₂. The new chitosan Schiff bases were grafted on silver nanoparticles, providing CS₁/Ag and CS₂/Ag structures. However, CS₁ and CS₂ and their silver nanoparticles were characterized by FT-IR, XRD, SEM-EDX, XRF, TEM, TGA, and DSC. The target

SUBMITTER: Hassan SM 

PROVIDER: S-EPMC11413560 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature