Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression.

ABSTRACT: Immunotherapy is an important cancer treatment method that offers hope for curing cancer patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption is the inability to benefit the majority of patients. The success or failure of immunotherapy is closely linked to the tumor's immune microenvironment. Recently, there has been significant attention on strategies to regulate the tumor immune microenvironment in order to stimulate anti-tumor immune responses in cancer immunotherapy. The distinctive physical properties and design flexibility of nanomedicines have been extensively utilized to target immune cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor cells (MDSCs), and tumor-associated fibroblasts (TAFs)), of

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11413684 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature