An iron-based metal-organic framework nanoplatform for enhanced ferroptosis and oridonin delivery as a comprehensive antitumor strategy.

ABSTRACT: Ferroptosis is a recently discovered pathway for regulated cell death pathway. However, its efficacy is affected by limited iron content and intracellular ion homeostasis. Here, we designed a metal-organic framework (MOF)-based nanoplatform that incorporates calcium peroxide (CaO₂) and oridonin (ORI). This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis, thereby enhancing ferroptosis therapy. Fused cell membranes (FM) were used to modify nanoparticles (ORI@CaO₂@Fe-TCPP, NPs) to produce FM@ORI@CaO₂@Fe-TCPP (FM@NPs). The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously, working in tandem with Fe³⁺ to induce ferroptosis. Photodynamic therapy (PDT) guided by porphyrin (

SUBMITTER: Cai M 

PROVIDER: S-EPMC11413704 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature