Mild-photothermal and nanocatalytic therapy for obesity and associated diseases.

ABSTRACT: Background: Current anti-obesity medications suffer from limited efficacy and side-effects because they act indirectly on either the central nervous system or gastrointestinal system. Herein, this work aims to introduce a transdermal photothermal and nanocatalytic therapy enabled by Prussian blue nanoparticles, which directly act on obese subcutaneous white adipose tissue (sWAT) to induce its beneficial remodeling including stimulation of browning, lipolysis, secretion of adiponectin, as well as reduction of oxidative stress, hypoxia, and inflammation. Methods: Prussian blue nanoparticles were synthesized and incorporated into silk fibroin hydrogel for sustained retention. The efficacy of mild photothermal (808 nm, 0.4 W/cm², 5 min) and nanocatalytic therapy (mPTT-

SUBMITTER: Zheng L 

PROVIDER: S-EPMC11413782 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature