Leucinostatins from fungal extracts block malaria transmission to mosquitoes.

ABSTRACT:

Background

Malaria is a mosquito-transmitted disease that kills more than half a million people annually. The lack of effective malaria vaccines and recently increasing malaria cases urge innovative approaches to prevent malaria. Previously, we reported that the extract from the soil-dwelling fungus Purpureocillium lilacinum, a common fungus from the soil, reduced Plasmodium falciparum oocysts in Anopheles gambiae midguts after mosquitoes contacted the treated surface before feeding.

Methods

We used liquid chromatography to fraction fungal crude extract and tract the active fraction using a contact-wise approach and standard membrane feeding assays. The purified small molecules were analyzed using precise mass spectrometry and tandem mass spectrometry.

Results

We isol

SUBMITTER: Niu G 

PROVIDER: S-EPMC11414030 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature