An anti-eCIRP strategy for necrotizing enterocolitis.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease characterized by intestinal inflammation and injury, with high mortality risk. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that propagates inflammation and tissue injury; however, the role of eCIRP in NEC remains unknown. We hypothesize that eCIRP exacerbates NEC pathogenesis and the novel eCIRP-scavenging peptide, milk fat globule-epidermal growth factor-factor VIII (MFG-E8)-derived oligopeptide 3 (MOP3), attenuates NEC severity, serving as a new therapeutic strategy to treat NEC.

Methods

Stool samples from premature neonates were collected prospectively and eCIRP levels were measured. Wild-type (WT) and CIRP^-/-

SUBMITTER: Nofi CP 

PROVIDER: S-EPMC11414128 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature