Repeated LPS induces training and tolerance of microglial responses across brain regions.

ABSTRACT:

Background

Neuroinflammation is involved in the pathogenesis of almost every central nervous system disorder. As the brain's innate immune cells, microglia fine tune their activity to a dynamic brain environment. Previous studies have shown that repeated bouts of peripheral inflammation can trigger long-term changes in microglial gene expression and function, a form of innate immune memory.

Methods and results

In this study, we used multiple low-dose lipopolysaccharide (LPS) injections in adult mice to study the acute cytokine, transcriptomic, and microglia morphological changes that contribute to the formation of immune memory in the frontal cortex, hippocampus, and striatum, as well as the long-term effects of these changes on behavior. Training and tolerance of gene expre

SUBMITTER: Kim J 

PROVIDER: S-EPMC11414187 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature