Plasma serotonergic biomarkers are associated with hypoxemia events in preterm neonates.

ABSTRACT:

Background

Hypoxemia is a physiological manifestation of immature respiratory control in preterm neonates, which is likely impacted by neurotransmitter imbalances. We investigated relationships between plasma levels of the neurotransmitter serotonin (5-HT), metabolites of tryptophan (TRP), and parameters of hypoxemia in preterm neonates.

Methods

TRP, 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), and kynurenic acid (KA) were analyzed in platelet-poor plasma at ~1 week and ~1 month of life from a prospective cohort of 168 preterm neonates <31 weeks gestational age (GA). Frequency of intermittent hypoxemia (IH) events and percent time hypoxemic (<80%) were analyzed in a 6 h window after the blood draw.

Results

At 1 week, infants with detectable plasma 5-HT had fewer IH even

SUBMITTER: MacFarlane PM 

PROVIDER: S-EPMC11414210 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature