The RNA-binding proteins regulate innate antiviral immune signaling by modulating pattern recognition receptors.

ABSTRACT: Viral infections pose significant threats to human health, leading to a diverse spectrum of infectious diseases. The innate immune system serves as the primary barrier against viruses and bacteria in the early stages of infection. A rapid and forceful antiviral innate immune response is triggered by distinguishing between self-nucleic acids and viral nucleic acids. RNA-binding proteins (RBPs) are a diverse group of proteins which contain specific structural motifs or domains for binding RNA molecules. In the last decade, numerous of studies have outlined that RBPs influence viral replication via diverse mechanisms, directly recognizing viral nucleic acids and modulating the activity of pattern recognition receptors (PRRs). In this review, we summarize the functions of RBPs in regulation of

SUBMITTER: Li J 

PROVIDER: S-EPMC11414252 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature