Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.

ABSTRACT:

Background

Wnt signaling pathways play crucial roles in animal development. They establish embryonic axes, specify cell fates, and regulate tissue morphogenesis from the early embryo to organogenesis. It is becoming increasingly recognized that these distinct developmental outcomes depend upon dynamic interactions between multiple ligands, receptors, antagonists, and other pathway modulators, consolidating the view that a combinatorial "code" controls the output of Wnt signaling. However, due to the lack of comprehensive analyses of Wnt components in several animal groups, it remains unclear if specific combinations always give rise to specific outcomes, and if these combinatorial patterns are conserved throughout evolution.

Results

In this work, we investigate the combinato

SUBMITTER: Vellutini BC 

PROVIDER: S-EPMC11414264 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature