Encapsulated lactiplantibacillus plantarum improves Alzheimer's symptoms in APP/PS1 mice.

ABSTRACT:

Background

Alzheimer's disease (AD) is a neurodegenerative disorder that can result in neurotoxicity and an imbalance in gut microbiota. Probiotics have been shown to play an important role in regulating the gut microbiota, but their viability and bioactivity are often compromised as they traverse the gastrointestinal tract, thereby reducing their efficacy and limiting their clinical utility.

Results

In this work, layer-by-layer (LbL) encapsulation technology was used to encapsulate Lactiplantibacillus plantarum (LP) to improve the above shortcomings. Studies in APPswe/PS1dE9 (APP/PS1) transgenic mice show that LbL-encapsulated LP ((CS/SP)₂-LP) protects LP from gastrointestinal damage while (CS/SP)₂-LP treatment It improves brain neuroinflammation and n

SUBMITTER: Hu F 

PROVIDER: S-EPMC11414319 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature