The Circadian Clock of Polarized Microglia and Its Interaction with Mouse Brain Oscillators.

ABSTRACT: The activity of the immune system is controlled by circadian clocks present in different immune cells. The brain-resident subtype of immune cells, microglia, exhibits a wide range of functional phenotypes depending on the signaling molecules in their microenvironment. The exact role of microglia in the hypothalamic suprachiasmatic nuclei (SCN), the central circadian clock, has not been known. Therefore, the aim of this study was to determine (1) whether microenvironment-induced changes in microglial polarization affect circadian clocks in these cells and (2) whether the presence of microglia contributes to SCN clock function. Microglial and SCN clocks were monitored using PER2-driven bioluminescence rhythms at the tissue and single-cell levels. We found that polarization of resting microgl

SUBMITTER: Honzlova P 

PROVIDER: S-EPMC11414434 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature