The Role of Tumor Necrosis Factor Following Spinal Cord Injury: A Systematic Review.

ABSTRACT: Pre-clinical studies place tumor necrosis factor (TNF) as a central player in the inflammatory response after spinal cord injury (SCI), and blocking its production and/or activity has been proposed as a possible treatment option after SCI. This systematic review provides an overview of the literature on the temporal and cellular expression of TNF after SCI and clarifies the potential for its therapeutic manipulation in SCI. A systematic search was performed in EMBASE (Ovid), MEDLINE (Ovid), and Web of Science (Core Collection). The search terms were the MeSH forms of tumor necrosis factor and spinal cord injury in the different databases, and the last search was performed on February 3, 2021. We found twenty-four articles examining the expression of TNF, with most using a thoracic contusiv

SUBMITTER: Lund MC 

PROVIDER: S-EPMC11414445 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature