Traumatic MicroRNAs: Deconvolving the Signal After Severe Traumatic Brain Injury.

ABSTRACT: History of traumatic brain injury (TBI) represents a significant risk factor for development of dementia and neurodegenerative disorders in later life. While histopathological sequelae and neurological diagnostics of TBI are well defined, the molecular events linking the post-TBI signaling and neurodegenerative cascades remain unknown. It is not only due to the brain's inaccessibility to direct molecular analysis but also due to the lack of well-defined and highly informative peripheral biomarkers. MicroRNAs (miRNAs) in blood are promising candidates to address this gap. Using integrative bioinformatics pipeline including miRNA:target identification, pathway enrichment, and protein-protein interactions analysis we identified set of genes, interacting proteins, and pathways that are connect

SUBMITTER: Cente M 

PROVIDER: S-EPMC11414451 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature