Directional Stimulus-Evoked Pallidal Electrophysiology in Primary Dystonia.

ABSTRACT:

Background

Deep brain stimulation for dystonia improves motor symptoms but variable and delayed responses challenge patient selection, targeting, and device programming.

Case report

Here we studied intracranial electrophysiology in a patient with primary dystonia and observed evoked resonant neural activity (ERNA) in the globus pallidus interna. These local stimulus-evoked potentials displayed refractory periods and paired-pulse facilitation at clinically relevant interstimulus intervals. Sensing from directional DBS contacts localized ERNA to an effective stimulation site in the ventral posterolateral portion of the pallidum.

Discussion

To the best of our knowledge, this is the first observation of ERNA in the globus pallidus interna in a patient with primary dystoni

SUBMITTER: Boddu AV 

PROVIDER: S-EPMC11414461 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature