Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.

ABSTRACT: Host-pathogen coevolution is defined as the reciprocal evolutionary changes in both species due to genotype × genotype (G×G) interactions at the genetic level determining the outcome and severity of infection. While co-analyses of hosts and pathogen genomes (co-genome-wide association studies) allow us to pinpoint the interacting genes, these do not reveal which host genotype(s) is/are resistant to which pathogen genotype(s). The knowledge of this so-called infection matrix is important for agriculture and medicine. Building on established theories of host-pathogen interactions, we here derive four novel indices capturing the characteristics of the infection matrix. These indices can be computed from full genome polymorphism data of randomly sampled uninfected hosts, as well as infected ho

SUBMITTER: Markle H 

PROVIDER: S-EPMC11414474 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature