Lipid metabolic rewiring in glioma‑associated microglia/macrophages (Review).

ABSTRACT: Gliomas are the most prevailing brain malignancy in both children and adults. Microglia, which are resident in the central nervous system (CNS), are distributed throughout the brain and serve an important role in the immunity of the CNS. Microglial cells exhibit varying phenotypic and metabolic properties during different stages of glioma development, making them a highly dynamic cell population. In particular, glioma‑associated microglia/macrophages (GAMs) can alter their metabolic characteristics and influence malignancies in response to the signals they receive. The significance of macrophage metabolic reprogramming in tumor growth is becoming increasingly acknowledged in recent years. However, to the best of our knowledge, there is currently a scarcity of data from investigations into

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11414527 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature