Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization.

ABSTRACT:

Background

Previous studies have identified a clinical association between gut microbiota and Obstructive sleep apnea (OSA), but the potential causal relationship between the two has not been determined. Therefore, we aim to utilize Mendelian randomization (MR) to investigate the potential causal effects of gut microbiota on OSA and the impact of OSA on altering the composition of gut microbiota.

Methods

Bi-directional MR and replicated validation were utilized. Summary-level genetic data of gut microbiota were derived from the MiBioGen consortium and the Dutch Microbiome Project (DMP). Summary statistics of OSA were drawn from FinnGen Consortium and Million Veteran Program (MVP). Inverse-variance-weighted (IVW), weighted median, MR-Egger, Simple Mode, and Weighted Mode meth

SUBMITTER: Liu L 

PROVIDER: S-EPMC11414551 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature