Degradation of STIM1 through FAM134B-mediated ER-phagy is potentially involved in cell proliferation.

ABSTRACT: Autophagy is classified as nonselective or selective depending on the types of degrading substrates. Endoplasmic reticulum (ER)-phagy is a form of selective autophagy for transporting the ER-resident proteins to autolysosomes. FAM134B, a member of the family with sequence similarity 134, is a well-known ER-phagy receptor. Dysfunction of FAM134B results in several diseases including viral infection, inflammation, neurodegenerative disorder, and cancer, indicating that FAM134B has crucial roles in various kinds of intracellular functions. However, how FAM134B-mediated ER-phagy regulates intracellular functions is not well understood. In this study, we found that FAM134B knockdown in mammalian cells accelerated cell proliferation. FAM134B knockdown increased the protein amount of stromal inte

SUBMITTER: Kajiho H 

PROVIDER: S-EPMC11414581 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature