Prognostic and Immunological Role of Cuproptosis-Related Gene MTF1 in Pan-Cancer.

ABSTRACT: Metal regulatory transcription factor 1 (MTF1) has been reported to induce the expression of metallothionein and other genes involved in metal homeostasis. However, the role of MTF1 in pan-cancer and tumor immunity remains unclear. In this study, we conducted a series of bioinformatics analyses to investigate the clinical significance and potential functions of MTF1 across various types of cancer. By employing bioinformatics algorithms and immunofluorescence assays, we analyzed the associations between MTF1 and immune infiltration in the tumor microenvironment as well as the expression levels of immune-related molecules. Our findings revealed dysregulation of MTF1 in pan-cancer along with its correlation with certain clinicopathological features, suggesting its diagnostic and prognostic va

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11414622 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature