Eosinophil-Associated Genes are Potential Biomarkers for Hepatocellular Carcinoma Prognosis.

ABSTRACT: Background: Eosinophils, a type of white blood cell originating from the bone marrow, are widely believed to play a crucial role in inflammatory processes, including allergic reactions and parasitic infections. However, the relationship between eosinophils and liver cancer is not well understood. Methods: Tumor immune infiltration scores were calculated using single-sample Gene Set Enrichment Analysis (ssGSEA). Key modules and hub genes associated with eosinophils were screened using Weighted Gene Co-expression Network Analysis (WGCNA). Univariate and multivariate Cox analyses, along with LASSO regression, were used to identify prognostic genes and create a risk model. The Tumor Immune Dysfunction and Exclusion (TIDE) score was used to evaluate the immunotherapeutic significa

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11414626 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature