Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles.

ABSTRACT: Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11414743 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature