Association between striatal amyloid deposition and motor prognosis in Parkinson's disease.

ABSTRACT:

Background and purpose

The co-occurrence of amyloid-β pathology in Parkinson's disease (PD) is common; however, the role of amyloid-β deposition in motor prognosis remains elusive. This study aimed to investigate the association between striatal amyloid deposition, motor complications and motor prognosis in patients with PD.

Methods

Ninety-six patients with PD who underwent ¹⁸F florbetaben (FBB) positron emission tomography were retrospectively assessed. The ratio of the striatum to global (STG) FBB uptake was obtained for each individual, and patients were allotted into low and high STG groups according to the median value. The effect of STG group on regional amyloid deposition, the occurrence of motor complications and longitudinal change in levodopa equivalent

SUBMITTER: Park M 

PROVIDER: S-EPMC11414803 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature