Rubella virus seropositivity after infection or vaccination as a risk factor for multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a demyelinating disease affecting millions of people worldwide. Hereditary susceptibility and environmental factors contribute to disease risk. Infection with Epstein-Barr virus (EBV) and human herpesvirus 6A (HHV-6A) have previously been associated with MS risk. Other neurotropic viruses, such as rubella virus (RV), are possible candidates in MS aetiopathogenesis, but previous results are limited and conflicting.

Methods

In this nested case-control study of biobank samples in a Swedish cohort, we analysed the serological response towards RV before the clinical onset of MS with a bead-based multiplex assay in subjects vaccinated and unvaccinated towards RV. The association between RV seropositivity and MS risk was analysed with condition

SUBMITTER: Ingvarsson J 

PROVIDER: S-EPMC11414808 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature