Construct prognostic models of multiple myeloma with pathway information incorporated.

ABSTRACT: Multiple myeloma (MM) is a hematological disease exhibiting aberrant clonal expansion of cancerous plasma cells in the bone marrow. The effects of treatments for MM vary between patients, highlighting the importance of developing prognostic models for informed therapeutic decision-making. Most previous models were constructed at the gene level, ignoring the fact that the dysfunction of the pathway is closely associated with disease development and progression. The present study considered two strategies that construct predictive models by taking pathway information into consideration: pathway score method and group lasso using pathway information. The former simply converted gene expression to sample-wise pathway scores for model fitting. We considered three methods for pathway score calcu

SUBMITTER: Wang S 

PROVIDER: S-EPMC11414978 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature