Molecular Signature Associated With Acute Rejection in Vascularized Composite Allotransplantation.

ABSTRACT:

Background

A deeper understanding of acute rejection in vascularized composite allotransplantation is paramount for expanding its utility and longevity. There remains a need to develop more precise and accurate tools for diagnosis and prognosis of these allografts, as well as alternatives to traditional immunosuppressive regimens.

Methods

Twenty-seven skin biopsies collected from 3 vascularized composite allotransplantation recipients, consisting of face and hand transplants, were evaluated by histology, immunohistochemistry staining, and gene expression profiling.

Results

Biopsies with clinical signs and symptoms of rejection, irrespective of histopathological grading, were significantly enriched for genes contributing to the adaptive immune response, innate immune r

SUBMITTER: Cassidy MF 

PROVIDER: S-EPMC11415116 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature