Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice.

ABSTRACT: The prognosis of ischemic stroke patients is highly associated with the collateral circulation. And the competing endogenous RNAs (ceRNAs) generated from different compensatory supply regions may also involve in the regulation of ischemic tissues prognosis. In this study, we found the apoptosis progress of ischemic neurons in posterior circulation-supplied regions (close to PCA, cortex2) was much slower than that in anterior circulation-supplied territory (close to ACA, cortex1) in MCAO-3-h mice. Using the RNA sequencing and functional enrichment analysis, we analyzed the difference between RNA expression profile in cortex1 and cortex2 and the related biological processes. The results indicated that the differential expressed ceRNAs in cortex1 were involved in cell process under acute inju

SUBMITTER: Zang J 

PROVIDER: S-EPMC11415153 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature