Clinical Prognostic Implications of Wnt Hub Genes Expression in Medulloblastoma.

ABSTRACT: Medulloblastoma is the most common type of pediatric malignant primary brain tumor, and about one-third of patients die due to disease recurrence and most survivors suffer from long-term side effects. MB is clinically, genetically, and epigenetically heterogeneous and subdivided into at least four molecular subgroups: WNT, SHH, Group 3, and Group 4. We evaluated common differentially expressed genes between a Brazilian RNA-seq GSE181293 dataset and microarray GSE85217 dataset cohort of pediatric MB samples using bioinformatics methodology in order to identify hub genes of the molecular subgroups based on PPI network construction, survival and functional analysis. The main finding was the identification of five hub genes from the WNT subgroup that are tumor suppressors, and whose lower expr

SUBMITTER: Martins-da-Silva A 

PROVIDER: S-EPMC11415171 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature