Environmental Enrichment Protects Offspring of a Rat Model of Preeclampsia from Cognitive Decline.

ABSTRACT: Preeclampsia affects 5-7% of all pregnancies and contributes to adverse pregnancy and birth outcomes. In addition to the short-term effects of preeclampsia, preeclampsia can exert long-term adverse effects on offspring. Numerous studies have demonstrated that offspring of preeclamptic women exhibit cognitive deficits from childhood to old age. However, effective ways to improve the cognitive abilities of these offspring remain to be investigated. The aim of this study was to explore whether environmental enrichment in early life could restore the cognitive ability of the offspring of a rat model of preeclampsia and to investigate the cellular and molecular mechanisms by which EE improves cognitive ability. L-NAME was used to establish a rat model of preeclampsia. The spatial learning and m

SUBMITTER: Lu H 

PROVIDER: S-EPMC11415177 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature