Monitoring and stopping Hymenoptera venom immunotherapy: Contribution of IgE blocking activity.

ABSTRACT:

Background

Hymenoptera venom allergy is a public health issue and has an undeniable impact on quality of life. Allergen immunotherapy (AIT) has shown long-term efficacy in this severe and potentially lethal allergy. However, no biomarker can predict the effectiveness of this treatment.

Objectives

We evaluated the contribution of IgE blocking activity, a functional biomarker carried out in our center using flow cytometry, to predict the efficacy of AIT.

Methods

This retrospective study from 1985 to 2022 describes in detail the demographic, clinical, and biological characteristics of patients who benefited from AIT with Hymenoptera venom at the University Hospital of Limoges. The outcome measure used was the presence of anaphylactic reaction (grade I to IV according to

SUBMITTER: Poulat J 

PROVIDER: S-EPMC11415340 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature