Evaluating the association between placenta DNA methylation and cognitive functions in the offspring.

ABSTRACT: The placenta plays a crucial role in protecting the fetus from environmental harm and supports the development of its brain. In fact, compromised placental function could predispose an individual to neurodevelopmental disorders. Placental epigenetic modifications, including DNA methylation, could be considered a proxy of placental function and thus plausible mediators of the association between intrauterine environmental exposures and genetics, and childhood and adult mental health. Although neurodevelopmental disorders such as autism spectrum disorder have been investigated in relation to placenta DNA methylation, no studies have addressed the association between placenta DNA methylation and child's cognitive functions. Thus, our goal here was to investigate whether the placental DNA meth

SUBMITTER: Diez-Ahijado L 

PROVIDER: S-EPMC11415363 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature