M6A/m1A/m5C-Associated Methylation Alterations and Immune Profile in MDD.

ABSTRACT: Major depressive disorder (MDD) is a prevalent psychiatric condition often accompanied by severe impairments in cognitive and functional capacities. This research was conducted to identify RNA modification-related gene signatures and associated functional pathways in MDD. Differentially expressed RNA modification-related genes in MDD were first identified. And a random forest model was developed and distinct RNA modification patterns were discerned based on signature genes. Then, comprehensive analyses of RNA modification-associated genes in MDD were performed, including functional analyses and immune cell infiltration. The study identified 29 differentially expressed RNA modification-related genes in MDD and two distinct RNA modification patterns. TRMT112, MBD3, NUDT21, and IGF2BP1 of the

SUBMITTER: Ren X 

PROVIDER: S-EPMC11415454 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature