Dietary fat content and absorption shape standard diet devaluation through hunger circuits.

ABSTRACT:

Objective

Exposure to 60% high fat diet (HFD) leads to a robust consummatory preference over well-balanced chow standard diet (SD) when mice are presented with a choice. This passive HFD-induced SD devaluation following HFD challenge and withdrawal is highlighted by the significant reduction in SD food intake even in states of caloric deprivation. The elements of HFD that lead to this SD depreciation remains unclear. Possibly important factors include the amount and type of fat contained in a diet as well as past eating experiences dependent on sensory properties including taste and post ingestive feedback. We aimed to explore the role of these components to HFD-induced SD devaluation.

Methods

Wildtype mice were longitudinally presented discrete HFDs in conjunction with SD a

SUBMITTER: Sutton Hickey AK 

PROVIDER: S-EPMC11415638 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature