Mid-pass whole-genome sequencing in a Malagasy cohort uncovers body composition associations.

ABSTRACT: The majority of human genomic research studies have been conducted in European-ancestry cohorts, reducing the likelihood of detecting potentially novel and globally impactful findings. Here, we present mid-pass whole-genome sequencing data and a genome-wide association study in a cohort of 264 self-reported Malagasy individuals from three locations on the island of Madagascar. We describe genetic variation in this Malagasy cohort, providing insight into the shared and unique patterns of genetic variation across the island. We observe phenotypic variation by location and find high rates of hypertension, particularly in the Southern Highlands sampling site, as well as elevated self-reported malaria prevalence in the West Coast site relative to other sites. After filtering to a subset of 214 

SUBMITTER: Hamid I 

PROVIDER: S-EPMC11415767 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature