G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets.

ABSTRACT:

Background

Our prior genome-wide association study of thrombin-induced platelet aggregation identified a G protein-coupled receptor kinase 5 (GRK5) noncoding variant (rs10886430-G) that is strongly associated with increased platelet reactivity to thrombin. This variant predisposes to increased risk of stroke, pulmonary embolism, and venous thromboembolism.

Objectives

To determine role of platelet specific GRK5 in platelet responses to agonists and injury.

Methods

Platelets from GRK5 mutant mice have been shown to have increased thrombin sensitivity, indicating that GRK5 may be a negative regulator of platelet activation. However, this has not been studied in a platelet-specific manner. We therefore used platelet-specific GRK5 mutant mice and models of thrombosis and p

SUBMITTER: Li C 

PROVIDER: S-EPMC11415800 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature