Durable local control with hypofractionated radiation therapy for unresectable or metastatic melanoma.

ABSTRACT:

Background and purpose

As patients with advanced melanoma live longer in the context of systemic therapy advancements, better strategies for durable control of bulky tumors are needed. In this study, we evaluated if dose-escalated hypofractionated radiation therapy (HFRT) can provide durable local control and improve tumor-associated symptoms in patients with unresectable or bulky metastatic melanoma for whom stereotactic ablative radiotherapy (RT) approaches are not feasible due to tumor size or location.

Materials and methods

We retrospectively reviewed 49 patients with unresectable or bulky metastatic melanoma who were treated to a total of 53 tumor targets with 12-17 fractions HFRT at our institution between 2015-2022. Clinical scenarios included: unresectable, locoregio

SUBMITTER: Keatts SA 

PROVIDER: S-EPMC11415805 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature