SCIntRuler: guiding the integration of multiple single-cell RNA-seq datasets with a novel statistical metric.

ABSTRACT:

Motivation

The growing number of single-cell RNA-seq (scRNA-seq) studies highlights the potential benefits of integrating multiple datasets, such as augmenting sample sizes and enhancing analytical robustness. Inherent diversity and batch discrepancies within samples or across studies continue to pose significant challenges for computational analyses. Questions persist in practice, lacking definitive answers: Should we use a specific integration method or opt for simply merging the datasets during joint analysis? Among all the existing data integration methods, which one is more suitable in specific scenarios?

Result

To fill the gap, we introduce SCIntRuler, a novel statistical metric for guiding the integration of multiple scRNA-seq datasets. SCIntRuler helps researchers ma

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC11415828 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature