"Multi-layer" encryption of medical data in DNA for highly-secure storage.

ABSTRACT: The exponential increasement and the attributes of medical data drive the requirement for secure medical data archiving. DNA data storage shows promise for storing sensitive and important data like medical records due to its high density and endurance. Nevertheless, current DNA data storage working scheme generally does not fully consider the data encryption, posing a risk of data corruption by routine DNA sequencing. Here, we designed a "multi-layer" encryption pipeline for medical data archiving. Initially, digital information was encrypted using Blowfish algorithm at information technology (IT) layer, followed by two-layer data encryption at the biotechnology (BT) layer. The first BT layer exploited the molecular weight of synthetic DNA or nucleoside to encrypt the key, while the second

SUBMITTER: Xu J 

PROVIDER: S-EPMC11415972 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature