Synergistic effect of curcumin and tamoxifen loaded in pH-responsive gemini surfactant nanoparticles on breast cancer cells.

ABSTRACT:

Background

Drug combination therapy is preferred over monotherapy in clinical research to improve therapeutic effects. Developing a new nanodelivery system for cancer drugs can reduce side effects and provide several advantages, including matched pharmacokinetics and potential synergistic activity. This study aimed to examine and determine the efficiency of the gemini surfactants (GSs) as a pH-sensitive polymeric carrier and cell-penetrating agent in cancer cells to achieve dual drug delivery and synergistic effects of curcumin (Cur) combined with tamoxifen citrate (TMX) in the treatment of MCF-7 and MDA-MB-231 human BC cell lines.

Methods

The synthesized NPs were self-assembled using a modified nanoprecipitation method. The functional groups and crystalline form of the nano

SUBMITTER: Ashin ZF 

PROVIDER: S-EPMC11415995 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature