Gegen Qinlian decoction alleviates depression-like behavior by modulating the gut microenvironment in CUMS rats.

ABSTRACT:

Background

Gegen Qinlian Decoction (GQD) is a classical traditional Chinese medicine (TCM) formula primarily utilized for treating gut disorders. GQD showed therapeutic effects on several diseases in clinical and animal studies by targeting gut microbes. Our recent studies also found that GQD efficiently alleviated anxiety in methamphetamine-withdrawn mice via regulating gut microbiome and metabolism. Given that various studies have indicated the link between the gut microbiome and the development of depression, here we endeavor to explore whether GQD can manage depression disorders by targeting the gut microbiome.

Methods and materials

The depression-like model was induced in rats through chronic unpredictable mild stress (CUMS) and the depression levels were determined usi

SUBMITTER: Peng Y 

PROVIDER: S-EPMC11416015 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature