β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation.

ABSTRACT:

Aims

The mechanisms regulating the cellular behaviour and cardiomyocyte organization during ventricular wall morphogenesis are poorly understood. Cardiomyocytes are surrounded by extracellular matrix (ECM) and interact with ECM via integrins. This study aims to determine whether and how β1 integrins regulate cardiomyocyte behaviour and organization during ventricular wall morphogenesis in the mouse.

Methods and results

We applied mRNA deep sequencing and immunostaining to determine the expression repertoires of α/β integrins and their ligands in the embryonic heart. Integrin β1 subunit (β1) and some of its ECM ligands are asymmetrically distributed and enriched in the luminal side of cardiomyocytes, and fibronectin surrounds cardiomyocytes, creating a network for them. Itgb1

SUBMITTER: Miao L 

PROVIDER: S-EPMC11416060 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature