Vascular risk burden is a key player in the early progression of Alzheimer's disease.

ABSTRACT: Understanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's disease (AD) progression is important in the context of emerging treatments for preclinical AD. In a group of 503 cognitively unimpaired individuals, we tested whether VRF burden interacts with AD pathophysiology to accelerate neurodegeneration and cognitive decline. Baseline VRF burden was calculated considering medical data and AD pathophysiology was assessed based on cerebrospinal fluid (CSF) amyloid-β_1-42 (Aβ_1-42) and tau phosphorylated at threonine 181 (p-tau₁₈₁). Neurodegeneration was assessed with plasma neurofilament light (NfL) and global cognition with the modified version of the Preclinical Alzheimer's Cognitive Composite. The mean (SD) age of participants w

SUBMITTER: Ferrari-Souza JP 

PROVIDER: S-EPMC11416150 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature