Identification and biophysical characterization of epitope atlas of Porcine Reproductive and Respiratory Syndrome Virus.

ABSTRACT: Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) have been a critical threat to swine health since 1987 due to its high mutation rate and substantial economic loss over half a billion dollar in USA. The rapid mutation rate of PRRSV presents a significant challenge in developing an effective vaccine. Even though surveillance and intervention studies have recently (2019) unveiled utilization of PRRSV glycoprotein 5 (GP5; encoded by ORF5 gene) to induce immunogenic reaction and production of neutralizing antibodies in porcine populations, the future viral generations can accrue escape mutations. In this study we identify 63 porcine-PRRSV protein-protein interactions which play primary or ancillary roles in viral entry and infection. Using genome-proteome annotation, protein

SUBMITTER: Dey S 

PROVIDER: S-EPMC11416235 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature