An Updated Simplified Severity Scale for Age-Related Macular Degeneration Incorporating Reticular Pseudodrusen: Age-Related Eye Disease Study Report Number 42.

ABSTRACT:

Purpose

To update the Age-Related Eye Disease Study (AREDS) simplified severity scale for risk of late age-related macular degeneration (AMD), including incorporation of reticular pseudodrusen (RPD), and to perform external validation on the Age-Related Eye Disease Study 2 (AREDS2).

Design

Post hoc analysis of 2 clinical trial cohorts: AREDS and AREDS2.

Participants

Participants with no late AMD in either eye at baseline in AREDS (n = 2719) and AREDS2 (n = 1472).

Methods

Five-year rates of progression to late AMD were calculated according to levels 0 to 4 on the simplified severity scale after 2 updates: (1) noncentral geographic atrophy (GA) considered part of the outcome, rather than a risk feature, and (2) scale separation according to RPD status (determined

SUBMITTER: Agron E 

PROVIDER: S-EPMC11416341 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature